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Anti botulinum toxin

Anti Botulinum Neurotoxin Type A (Chicken lgY) are valuable research tools in studies aimed at elucidating the mechanisms involved in vesicle trafficking and the extreme toxicity, as well as in gaining an understanding of the underlying events of synaptic transmission.

Buy Anti botulinum toxin Online

Anti Botulinum Neurotoxin Type A (Chicken lgY) are valuable research tools in studies aimed at elucidating the mechanisms involved in vesicle trafficking and the extreme toxicity, as well as in gaining an understanding of the underlying events of synaptic transmission. In addition to studies with the 150 kD holotoxin, recombinant nontoxic heavy chains can be used to evaluate the binding properties of the toxins and the recombinant nontoxic light chains can be used to screen for inhibition of the enzymatic activity of the protease domain.


The toxins produced by various strains of Clostridium botulinum are the strongest biotoxins known. In humans these toxins are responsible for food poisoning (botulism) caused by the growth of the bacterium under anaerobic conditions e. g. in canned food. The poisoning manifests itself as a symmetrical paralysis culminating in death caused by respiratory failure. The toxins are produced as binary proteins that possess a heavy chain (approximately 100kDa) and a light chain (approximately 50kDa).

The heavy chain is a binding component that directs the toxin to vulnerable cells, and the light chain is an enzyme that has mono (ADP-ribosyl) ating activity. The toxins are divided into 7 groups named A, B, C, D, E, F, and G where A, B, E, and F are associated with human disease and C and D mainly with disease in animals (cattle). Type G is not known to cause human disease. Botulinum toxin is a protein produced by the bacterium Clostridium botulinum, and is considered the most powerful neurotoxin ever discovered. Botulinum toxin causes Botulism poisoning, a serious and life-threatening illness in humans and animals. When introduced intravenously in monkeys, type A (Botox Cosmetic) of the toxin exhibits an LD50 of 40-56ng, type C1 around 32ng, type D 3200ng, and type E 88ng, rendering the above types some of the most powerful neurotoxins known. Popularly known by one of its trade names, Botox or Dysport or Xeomin, it is used for various cosmetic and medical procedures.

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